CBDa has many properties similar to CBD (cannabidiol). In vitro, CBDa showed anti-inflammatory, antimicrobial and tumor-inhibiting properties and also suppressed nausea and vomiting, according to scientific studies conducted by the DDr. CBDA has anti-inflammatory characteristics and may be able to relieve inflammation due to its characteristics as a selective Cox-2 inhibitor. Cyclooxygenase (Cox) 1 and 2 enzymes have different responsibilities.
However, recent research shows that crude cbda oil has its own unique potential. A study showed that CBDA could act as an effective anti-inflammatory agent. As more studies are conducted, the overlooked molecule begins to show greater effectiveness against inflammation compared to CBD. CBDa selectively inhibited cyclooxygenase (COX) -2 activity at 50% concentration.
The main objective of this review was to gather real knowledge of CBDA, in order to continue to acquire new ideas and new bioanalysis perspectives day by day for its future exploitation. Meanwhile, CBDA is in the early stages of research, but it shows just as much, if not more, promise than CBD. The main difference between CBDA and CBD is that CBDA is a chemical precursor to cannabidiol (CBD), similar but not acidic. CBDA oil can be consumed or absorbed through tinctures, raw cannabis juice, topical creams, and raw CBDA oil.
In a process called decarboxylation, CBDA, THCA and other acidic compounds are converted into their decarboxylated forms, known as the main psychoactive cannabinoids (THC, CBC, CBD, etc.) that can positively affect the body. In particular, hemp pollen (HP), which is a resin produced by isolating trichomes from plant inflorescences by a screening process, was selected as a source of CBDA. A different study by Rock et al demonstrated (albeit in a rodent model) that CBDa was a more effective anti-inflammatory than CBD or THC, the psychoactive compound found in cannabis indica (marijuana) and, to a much lesser extent, in cannabis sativa (hemp). In most cannabis plants, CBDA is present in only very small amounts, although some plants have been bred to contain balanced levels of CBDA and THCA.
While research on much of the potential of CBDA is still in its early stages, there is sufficient evidence that gives scientists and avid supplement users great optimism. So, while “better is a difficult judgment to find, there is enough early evidence to suggest that CBDA has its own distinctive qualities that may differentiate it from CBD in certain areas. A preclinical study focusing on the downregulation of Cox-2 enzymes found that CBDA could help suppress the spread of a specific type of breast cancer cells. While most cannabinoids bind directly to CB1 or CB2 receptors, CBDA doesn't work in this way.
In this study in animal models, CBDA showed “significantly greater potency in inhibiting vomiting in shrews and nausea in rats compared to CBD. If you use CBD products such as CBD oil or can benefit from their potential benefits, a small dose of CBDA products can be a worthwhile treatment option. COX-2 enzymes are associated with inflammation following injury or infection, so by blocking COX-2 enzymes, CBDA can relieve inflammation and associated pain.